Increasing Sweep Gas Flow Reduces Respiratory Drive and Dyspnea in Nonintubated Venoarterial Extracorporeal Membrane Oxygenation Patients: A Pilot Study
Danavorexton (TAK-925): A Promising Breakthrough in Combating Opioid-Induced Respiratory Depression Danavorexton (TAK-925): A Promising Breakthrough in Combating Opioid-Induced Respiratory Depression Opioids remain a cornerstone of pain management in clinical settings, yet their use is shadowed by life-threatening side effects, including respiratory depression and excessive sedation. A recent podcast episode from Anesthesiology ’s featured author series highlights a groundbreaking solution: danavorexton (TAK-925) , an orexin receptor 2 agonist that could revolutionize how we manage opioid-related complications. What Is Danavorexton (TAK-925)? Danavorexton is a selective agonist of the orexin-2 receptor (OX2R), a key player in regulating wakefulness and respiration. Orexins (also known as hypocretins) are neuropeptides produced in the hypothalamus that activate OX1R and OX2R receptors, influencing arousal, appetite, and...
Briefing Doc: Vein of Galen Malformation (VOGM) Source: OpenAnesthesia. “Vein of Galen Malformation”. Last updated 01/03/2025. Accessed 14/03/2025. Main Themes: Pathophysiology and Clinical Presentation of VOGM: VOGM is a rare congenital arteriovenous fistula posing significant health risks due to its impact on intracranial circulation and the cardiopulmonary system. Diagnosis and Treatment: Early diagnosis is crucial, typically through prenatal ultrasound. Endovascular embolization is the primary treatment, requiring careful anesthetic management. Anesthetic Considerations for VOGM Embolization: Anesthesia for VOGM embolization requires specialized expertise due to the complex physiology, potential cardiac and pulmonary complications, and risk of complications during the procedure. Listen Podcast Key Ideas/Facts: 1. Definition and Impact: "The VOGM is a rare congenital arteriovenous fistula that results in low-resistance intracranial circulation and downstream cardiopulmona...