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Associations Between Nonanemic Iron Deficiency and Postoperative Outcomes in Cardiac Surgery: A Systematic Review and Meta-Analysis

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BACKGROUND: Preoperative screening for iron deficiency is a part of patient blood management protocols. This systematic review, meta-analysis, and meta-regression reviews the association between nonanemic iron deficiency and postoperative outcomes in patients undergoing cardiac surgery. We aimed to determine whether preoperative screening for nonanemic iron deficiency should be recommended in patients undergoing cardiac surgery. METHODS: Electronic databases MEDLINE (Ovid), Embase (Ovid), and Scopus were searched from inception until December 9, 2022. Studies were considered for inclusion if they (1) used an observational study design; (2) enrolled adult patients undergoing cardiac surgery; and (3) included an iron-deficient and iron-replete group, defined using serum ferritin and/or transferrin saturation. The primary outcome was the length of acute hospital stay. Secondary outcomes included length of intensive care unit stay, requirement for allogeneic red blood cell transfusion, num...
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Continuous vs. Bolus Norepinephrine for Post-Induction Hypotension

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Continuous vs. Bolus Norepinephrine for Post-Induction Hypotension Continuous vs. Bolus Norepinephrine for Post-Induction Hypotension: A Landmark Trial Key Takeaway: Continuous infusion of norepinephrine offers no significant advantage over manual bolus administration in reducing post-induction hypotension in low-to-moderate risk noncardiac surgery patients, according to a randomized trial in the British Journal of Anaesthesia . Study Design Participants: 276 patients (261 analyzed) undergoing elective noncardiac surgery Interventions: Randomized to continuous infusion (target: 0.05 µg/kg/min) or manual boluses (10 µg) Monitoring: Intermittent oscillometric BP + blinded continuous finger-cuff monitoring Primary Endpoint: Area under MAP Key Findings Metric Continuous Infusion Bolus Administration Area under MA...
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